Hotspots for Mental Illnesses Pinpointed

The review lined in this summary was released on as a preprint and has not but been peer-reviewed.

Crucial Takeaway

  • Geographic variation in the incidence of bipolar problem, schizophrenia, and important depressive disorder can be established utilizing a longitudinal health-related-records databases.

Why This Issues

Study Style and design

  • The workforce analyzed facts from electronic health documents and discovered 16,295 persons who obtained a major prognosis of bipolar condition, schizophrenia, or big depressive disorder at a psychiatric hospital in Caldas, Colombia.

  • Researchers examined the effect of vacation time to that medical center on the incidence of these psychiatric ailments, and employed spatial-scan studies to discover clusters of sufferers stratified by prognosis and disease severity.

Essential Benefits

  • A significate correlation concerning travel time to the hospital and incidence was noticed for outpatients with mild ailment (relative chance [RR], .80 95% CI, .71 – .89 P < .001), but not for in-patients with severe disease. This observation was mostly driven by patients with major depressive disorder.

  • Seven distinct clusters of severe mental illness were identified, all of which had significant over-representation of bipolar disorder.

  • The first cluster around the hospital, which is located in a metropolitan area, had the highest likelihood for each of the three mental disorders and had the greatest over-representation of major depressive disorder (RR, 5.47 < .001).

  • The second cluster, located 1.5 hours from the hospital, had the greatest over-representation of severe bipolar disorder (RR, 5.83 < .001), and has one of the highest annual worldwide frequencies, at 8.7 inpatients per 10,000 residents.

  • Other hotspots demonstrated patterns of over-representation differentiated by diagnosis.


  • The location of residence prior to a patient’s first recorded hospital visit, which is needed to investigate the impact of environmental factors, such as displacement, was not assessed in the analysis.

  • The study focused on the primary diagnosis, and does not account for variability in disease trajectories.


  • This study was supported by NIH grants R01MH113078, R01MH123157, R00MH116115, and R56 AI152759.

  • The authors have declared no competing interest.

This is a summary of a preprint research study, Geospatial analysis reveals distinct hotspots of severe mental illness, written by Janet Song, BSc, from the Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, and colleagues, published on and provided to you by Medscape. This study has not yet been peer-reviewed. The full text of the study can be found on

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